一起医院内群体性诺如病毒急性胃肠炎的调查

An Acute Norovirus Gastroenteritis Outbreak in A Hospital

目的对一起发生在北京市某医院的群体性诺如病毒急性肠胃炎进行调查和分析。方法采用现场流行病学方法进行调查,PCR检测患者粪便标本,Western blot检测患者血清抗体。结果本次疫情流行26d,共发病87例,其中住院患者65例,医护人员15例,陪护人员6例,配餐员1例。PCR检查示20例患者粪便标本中,12例诺如病毒核酸检测为阳性。Westernblot检测示24例患者血标本中,19例诺如病毒抗体为强阳性。通过隔离治疗患者、加强消毒和卫生宣教等综合措施,疫情得到有效控制。结论本次急性胃肠炎暴发疫情由诺如病毒引起,感染来源尚不明确。

Objective To investigate and analyze a case of acute norovirus gastroenteritis outbreak in a hospital. Methods Data were collected through by polymerase chain reaction-reverse transcription Results The outbreak lasted 26 days. A total of the on-the-spot investigation and faecal specimens were tested （RT-PCR）. Serum specimens were tested by Western blot. 87 cases were reported, including 65 inpatients, 15 healthcare workers, 6 accompanies, and 1 pantryman. Twelve （60%） of 20 stool specimens were norovirus-positive by RT-PCR and 19 of 24 blood samples were norovirus-positive by Western blot. The outbreak was effectively controlled by isolating and treating the patients, extensive disinfection, and health education. Conclusion The gastroenteritis outbreak was caused by norovirns with unkown infection source.