摘要
二磷酸盐（bisphosphonate，BPs）是一类焦磷酸类似物，与焦磷酸不同的是以P—C—P键代替焦磷酸盐中P—C—P键（见图），这种变化改变了二磷酸盐的体内代谢过程，使其可以抵抗水解酶的降解，而保持一定的稳定性。1968年根据其具有显著的抑制烃基磷酸钙结晶溶解的生物特性，用于骨代谢疾病的治疗。目前，BPs已经发展到第三代（表1），广泛用于恶性骨疾病尤其是骨质疏松和恶性肿瘤骨转移的治疗。
出处
《中国医药导刊》
2008年第7期1062-1064,共3页
Chinese Journal of Medicinal Guide
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