转录信号传导子与激活子3在宫颈癌及宫颈癌上皮内瘤变中的表达及临床意义

Expression and Clinical Significance of Stat3 in Cervical Carcimomas and Cervical Intraepithelial Neoplasia

目的探讨转录信号传导子与激活子3(Stat3)在宫颈鳞状细胞癌和宫颈上皮内瘤变(CIN)中的表达及与临床病理特征的关系,及其在宫颈癌病变中的可能作用。方法应用免疫组织化学SP法,检测44例宫颈鳞状细胞癌,50例宫颈上皮内瘤变,15例正常宫颈组织中Stat3蛋白的表达水平。结果Stat3在宫颈鳞状细胞癌组中的阳性表达率为84.1%(37/44),明显高于宫颈上皮内瘤变组,P<0.05;亦明显高于正常宫颈组织,P<0.01;同时发现Stat3表达率与宫颈癌组织学分期有关,P<0.05。结论Stat3过表达可能在宫颈鳞状细胞癌的发生、发展及分化过程中起重要作用。

Objective To assess the expression of signal transducers and activation of transcription3 in cervical squamous cell carcimoma and cervical intraepithelial neoplasia,and to evaluate its relationship with cliniclopathological parameters.Methods Expression of Stat3 protein was determined by immunohistochemical method in 15 normal cervical tissues,50 cervical intraepithelial neoplasia and 44 cervical squamous cell carcimomas.Results The expression rate of Stat3 was 84.1%（37/44）in squamous cell carcinoma,which was significantly higher than that in the cervical intraepithelial neoplasia（P〈0.05）and normal cervical tissues（P〈0.01）,respectively.Stat3 protein expression was correlated with the histological grade（P〈0.05）.Conclusion The overexpression of Stat3 may have an improtant role in the development and differentiation of cervical carcinoma.