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Bcl-2蛋白小分子抑制剂的研究进展 被引量：2

Progress in the research of small-molecule inhibitors of Bcl-2 proteins
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摘要 目的对近年来Bcl-2蛋白小分子抑制剂的研究进展作以综述。方法根据近期对Bcl-2蛋白小分子抑制剂的21篇相关文献进行整理和归纳。结果和结论Bcl-2蛋白是很有开发潜力的靶点,依据此靶点而设计出的Bcl-2蛋白小分子抑制剂,可以消除或减弱癌细胞对凋亡的耐药性,有望成为新一代抗癌药物。 Objective To review the progress in the research of small-molecule inhihitors of Bcl-2 proteins in recent years. Methods Twenty-one related papers on small-molecule inhibitors of Bcl-2 proteins were consulted and classified. Results and Conclusions Bcl-2 is a promising molecular target for the design of small- molecule inhibitors of Bcl-2 proteins which can overcome resistance of cancer cells to apoptosis.
作者 张淑兰 姚鹏 宫平
机构地区 沈阳药科大学制药工程学院
出处 《沈阳药科大学学报》 CAS CSCD 北大核心 2008年第11期919-923,共5页 Journal of Shenyang Pharmaceutical University
关键词 BCL-2 肿瘤 凋亡 小分子抑制剂 Bcl-2 tumor apoptosis small-molecule inhibitor
分类号 R914 [医药卫生—药物化学]
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参考文献21

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同被引文献18

  • 1向楠.中药临床型习里学.北京:中国医药科技出版社,2009:180-181.
  • 2Tilman Oltersdorf, Steven W Elmore, Alexander R Shoemaker, et al. An Inhibitor of Bcl-2 Family Proteins Induces Regression of Solid TumoursFJ]. Nature, 2005,435 (7042) : 677.
  • 3RW Rooswinkel,B Van de kooij,M Verheij,et al. Bcl-2 Is a Beta ter Abt-737 Target Than Bcl-xl Or Bcl-w and Only Noxa Overcomes Resistance Mediated By Mcl-1, Bfl-1, Or Bcl-h[J]. Cell Death & Disease,2012,3(8) :0.
  • 4Marina Konopleva,Rooha Contractor, Twee Tsao, et al. Mechanisms of Apoptosis Sensitivity and Resistance to the Bh3 Mimetic Abt-737 in Acute Myeloid Leukemia[J]. Cancer Cell, 2006, 10 (5) : 375.
  • 5Derek Yecies,Nicole E Carlson,Jing Deng,et al. Acquired Re- sistance to Abt 737 in Lymphoma Cells That Up-regulate Mcl-1 and Bfl-1[J]. Blood,2010,115(16) :3304.
  • 6Mark S Cragg, Claire Harris, Andreas Strasser, et al. Unleashing the Power of Inhibitors of Oncogenic Kinases Through Bh3 Mitactics[J1. Nature Reviews Cancer, 2009,9 (5) : 321.
  • 7CA Homewood, DC Warhurst, W Peters, et al. Lysosomes, Ph and the Anti-malarial Action of Chloroquine[J]. Nature, 1972, 235(7) :50.
  • 8Andrew FG Slater. Chloroquine:Mechanism of Drug Action'and Resistance In< I> Plasmodium Falciparum [J]. Pharmacology Therapeutics, 1993,57 (2):203.
  • 9John FR Kerr,Clay M Winterford,Brian V Harmon. Apoptosis. Its Significance in Cancer and Cancer Therapy[J]. Cancer, 1994, 73(8) :2013.
  • 10Clemens A Schmitt,Scott W Lowe. Apoptosis and Therapy[J]. The Journal of Pathology, 1999,187(1) : 127.

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沈阳药科大学学报
2008年 第11期

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