氯沙坦对老年原发性高血压血尿酸水平影响的研究

Study on effect of losartan on serum level of uric acid in senile primary hypertension patients

目的研究氯沙坦在治疗高血压合并高尿酸血症时对尿酸代谢水平的影响。方法选择高血压合并高尿酸血症老年患者90例,观察氯沙坦治疗8周后血尿酸的水平变化。结果氯沙坦治疗8周后尿酸水平为310.2±29.0μmol/L,与治疗前524.6±85.4μmol/L相比较,血尿酸水平有明显下降(P<0.01);且治疗后收缩压与舒张压均有明显下降(P<0.01)。结论氯沙坦降压同时能降低血尿酸。

Objective To study the effect of losartan on uric acid metabolism in patients with senile hypertension associated with hyperuricemia. Methods Ninty patients with senile hypertension and hyperuricemia were selected for study. The change in serum level of uric acid was observed after treatment by losartan for eight weeks. Results The mean level of serum uric acid was 310.2 ± 29.0 μmoL/L after losartan treatment for eight weeks. In comparison with pre - treatment level （ 524.6 ±85.4 μmoL/L）, the serum level of uric acid had apparently been reduced（ P 〈0.01 ）. And the levels of systolic pressure and diastolic pressure were significantly decreased after treatment（ P 〈0.01 ）. Conclusion Losar- tart cart reduce the blood pressure and it can also decrease the serum level of uric acid.