摘要
葛根素(Puerarin)临床应用广泛,但是其水溶性低,影响疗效的更好发挥。将葛根素键合到具有良好生物相容性、可降解的水溶性聚天冬酰胺衍生物(PDHEA)上,合成了葛根素前药(PDHEA-P),并通过FT-IR、1H-NMR验证了目标产物。研究表明,葛根素前药的水溶性大大提高,所得前药的缓释性能良好。
The low solubility of puerarin in water leads to its poor bioavailability as an oral drug. In this article, the polymer prodrug of puerarin（PDHEA-P） is synthesized by using polyaspartamide derivatives（PDHEA） which have characteristics of biocompatibility,degradation and good solubility in water as drug carrier. The chemical structures of the prodrug are identified by FT-IR and 1 H-NMR. Results show that the solubility of prodrug in water is increased greatly, and the release rate is satisfactory.
出处
《材料导报》
EI
CAS
CSCD
北大核心
2008年第10期150-152,共3页
Materials Reports
基金
国家高新技术研究发展计划(863)项目(2006AA03Z445)
科技部重大基础研究前期研究专项计划项目(2005CCA00400)
常州市科技攻关计划项目
常州市科教城导航计划项目
南京大学分析测试基金资助课题
关键词
聚天冬酰胺
葛根素前药
缓释
polyaspartamide, prodrug of puerarin, release
