依达拉奉对高血压脑出血患者SPECT、血浆ET、CGRP的影响

The Effects of Edaravone on SPECT、ET and CGRP in Patients with Hypertensive Intracerebral Hemorrhage

目的观察依达拉奉对高血压脑出血患者SPECT值、血浆ET、CGRP的影响,探讨依达拉奉治疗脑出血可能的机制。方法采用SPECT、放射免疫法分别对依达拉奉治疗组40例和常规治疗组40例及正常对照组30例的脑血流值,血浆ET、CGRP值进行检测分析。结果①入院时(0d)依达拉奉治疗组与常规组SPECT、ET、CGRP值比较,P>0.05,差异无统计学意义。②入院后(1、3、5d)依达拉奉治疗组与常规组SPECT、ET、CGRP值比较,P<0.05;常规组与正常对照组比较,P<0.01。差异有统计学意义。③ET与SPECT显著负相关(0.05水平);CGRP与SPECT显著正相关(0.01或0.05水平);ET与CGRP显著负相关(0.05水平)。结论依达拉奉通过降低血浆ET值,升高CGRP及SPECT值,对对高血压脑出血导致的脑损伤有一定保护作用。

Objective To observe the effects of edaravone on SPECT, ET and CGRP in patients with hypertensive intracerebral hemorrhage,in order to explore the possible mechanisms of edaravone for the treatment of cerebral hemorrhage. Methods To analyze the data of CBF given by SPECT and the levels of endothelin-1 （ET-1） ,Calcitonin gene-related peptide（CGRP） in the plasma of patients with cerebral hemorrhage investigated by radioimmunoassay, including edaravone therapy group（ n = 40） routine therapy group（ n = 40） and normal control group（ n = 30）. Results There was no statistical difference in the the levels of SPECT, ET and CGRP between edaravone group and routine group （ P 〉 0.05 ） ; After the treatment of edaravone, there was no statistical significance in the levels （ 1,3,5d） of SPECT, and ET-1, CGRP in plasma between edaravone group and routine groups（P 〈 0.01 ） ,and compared with control groups（P 〈 0. 05 ）. ET was negatively correlated with SPECT and CGRP （ P 〈 0.01, P 〈 0.05 ）. Conclusions Edaravone could protect brain tissue from second brain injury after hypertensive intracerebral hemorrhage by increasing the levels of CGRP and SPECT and decreasing the level of ET-1.