SNCG在胃癌中的表达及其与MMP-2,MMP-9的相关性

Expression of synuclein γ in gastric carcinoma and its relationship with MMP-2 and MMP-9

目的:研究SNCG在胃癌中的表达及意义,探讨SNCG与MMP-2,MMP-9在胃癌中表达的相关性.方法:采用免疫组化法检测60例胃癌及20例胃正常黏膜石蜡标本中SNCG蛋白和MMP-2、MMP-9的表达.结果:在胃癌组织中SNCG,MMP-2及MMP-9的表达阳性率均高于周围正常组织(65%,75%,68.3%vs0%,25%,20%,均P<0.05),他们的表达均与肿瘤浸润深度、淋巴结转移及肿瘤临床分期相关(P<0.05).SNCG的表达与MMP-2和MMP-9的表达呈正相关(r=0.383,0.552,均P<0.01),MMP-2的表达和MMP-9的表达呈正相关(r=0.352,P<0.01).结论:SNCG和MMP-2、MMP-9异常表达可能共同参与胃癌的发生、发展过程,SNCG和MMP-2、MMP-9可作为胃癌病理学特点的参考指标.

AIM： To study the expression and significance of synuclein γ （SNCG） in gastric cancer, and to explore the relationship between SNCG and MMP-2, and MMP-9 in gastric carcinoma. METHODS： Expression levels of SNCG protein, MMP-2, MMP-9 in sixty gastric cancer samples were detected using immuno-histochemical analysis and 20 paraffin wax samples of normal gastric mucosa were also detected and compared. RESULTS： The positive rates of SNCG, MMP-2 and MMP-9 were higher in gastric carcinoma than in neighboring normal tissues （65%, 75%, 68.3% vs 0%, 25%, 20%, all P 〈 0.05）. Their expression was positively correlated with depth of tumor infiltration, lymphatic metastasis, as well as the clinical staging of tumor （all P 〈 0.05）. Expression of SNCG was also positively correlated with that of MMP-2 and MMP-9 （r = 0.383, 0.552, both P 〈 0.01）. In addition, expression of MMP-2 was positively correlated with MMP-9 （r = 0.352, P 〈 0.01）. CONCLUSION： The aberrant expression of SNCG, MMP-2 and MMP-9 are likely to jointly participate in the process of genesis and development of gastric carcinoma, therefore the detection of SNCG, MMP-2 and MMP-9, which reflect the pathological characteristics of gastric cancer, could be regarded as a reference index.