P38 MAPK信号传导通路与胃癌关系的研究现状

Cumulating researches on the relationship between P38 MAPK signaling pathway and gastric carcinoma

丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPKs)级联反应是细胞内重要的信号传导系统之一,参与细胞生长、发育、分化和凋亡等一系列生理、病理过程.P38MAPK信号传导通路是MAPK通路的分支之一,介导了应激、炎性细胞因子、细菌产物等多种刺激引起的细胞反应,对细胞周期调控具有重要作用.但对不同的胃癌细胞系,或者不同的刺激,P38通路的作用不完全相同,甚至可能相反.提示对P38通路的功能仍需进一步的研究,他可能是肿瘤治疗的新靶点.

The cascade reaction of mitogen-activated protein kinases （MAPKs） is one of the vital intracellular signal transduction systems, participating in many physiological progressions, such as cell growth, proliferation, differentiation and apoptosis. P38 is a member of MAPKs, mediating many cell reactions induced by stress, inflammatory cytokines or bacterial products and playing a key role in the regulation of cell cycle. For different cell lines of gastric carcinoma, P38 has different functions. The same phenomenon can be seen when the cells are presented under different stimulus. P38 pathway may be one candidate target of cancer therapy.