摘要
脯氨酸作为一种结构简单、商品化的、廉价小分子手性催化剂,在多种不对称催化反应中表现出非常好的催化性能。本文综述了近年来脯氨酸直接催化的不对称有机反应涉及Aldol反应、Mannich反应、Michael反应、Diels-Alder反应、直接α-胺化反应、α-氧胺化反应、Baylis-Hillman反应、还原反应和氧化反应的进展并展望了其应用前景。
Proline has been gradually recognized as a simple, commercial and cheap chiral catalyst for many asymmetric reactions. The paper reviews recent advances in the development of direct proline-catalyzed asymmetric reactions including Aldol reaction, Mannich reaction, Michael reaction, Diels-Alder reaction, direct α-amination reaction, α-oxo amination reaction, Baylis-Hillman reaction, reduction reaction and oxidation reaction. It also puts forward the future application of proline.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2008年第11期1675-1686,共12页
Progress in Chemistry
基金
国家自然科学基金项目(No.20672061
20472032)资助
关键词
脯氨酸
催化
不对称反应
proline
catalysis
asymmetric reaction
