橙皮苷-铜配合物的结晶与抗氧化活性

Crystallization and Anti-oxidation Activity of Hesperidin-Copper(Ⅱ) Complex

中药有效成分配位后可产生新的或更好的药物活性。本文探讨了橙皮苷-铜的结晶工艺,并借助邻苯三酚自氧化法探讨其抗氧化活性。结果表明:在实验条件下,橙皮苷-铜配合物的最佳结晶工艺条件是:将30mL浓度为1.33×10-3mol/L的橙皮苷-铜(Ⅱ)溶液于40℃下缓慢搅拌20min,添加0.02g橙皮苷-铜(Ⅱ)晶种后冷藏过夜。其中温度对配合物结晶有显著影响;配合物对自由基O2-清除活性好于橙皮苷。本研究可为农业废弃橙皮的高值化利用提供参考。

The crystallizing technique of hesperidin-copper （Ⅱ） complex was studied, and its anti-oxidantion activity was also studied by the pyrogallol autoxidation method. Results showed that, the best crystallizatin technology were stirring 30 mL Hes-Cu（ Ⅱ） solution（1.33× 10^-3 mol/L） for 40 min at 20℃, and then refligerating it aider adding 0.02g of inoculating seed of Hes-Cu（Ⅱ）. Temperature showed a prominent effect on crystallization of the complex. And the hesperidin-copper（Ⅱ） complex have better anti-oxidation activity than hesperidin for O2-. This research can be a reference to the recycle of orange peel.