再发脑梗死患者血浆D-二聚体与纤维蛋白原变化的临床意义

Clinical significance of the dynamic change of D-Dimer and fibrinogen in patients with acute cerebral re-infarction

目的探讨脑再梗死患者与初次脑梗死患者的血浆D-二聚体、纤维蛋白原的改变。方法分别对68例初次脑梗死患者及68例脑再梗死患者的血浆D-二聚体、纤维蛋白原进行测定并对不同脑再梗死体积患者血浆D-二聚体、纤维蛋白原含量进行对比。结果再次脑梗死组血浆D-二聚体、纤维蛋白原均高于初次脑梗死组(P<0.05);在再次脑梗死组大面积梗死灶患者血浆D-二聚体、纤维蛋白原含量明显高于中、小面积梗死灶者(P<0.05)。结论血浆D-二聚体、纤维蛋白原的变化与脑再梗死的发生及预后有一定的关系,是再发脑梗死事件的重要危险因素。

Objective To study the dynamic data of D-Dimer and fihrinogen in patients with acute cerebral re-infarction , and explore the clinical significance and value. Methods The dynamic data of plasma D-Dimer （D-D） ,fibrinogen（Fg） of 68 patients with acute cerebral re-infarction and 68 patients with acute cerebral infarction were observed. And the infarction size of these patients was observed. Results Compared with the primary cerebral infarction group , Fg levels and D-Dimer levels of cerebral re-infarction group were significantly increased（P〈0. 05）. Fg levels and plasma D-Dimer level were significantly increased（P〈0. 05）in large size of cerebral re-infarction group compared with middle and small size. Conclusion The changes of plasma D-Dimer,fibrinogen are associated with the occurance and prognosis of re-cerebral infarction and those are the risk factors of cerebral re-infarcion.