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NuMA蛋白的生物学作用及其研究进展 被引量：1

Biological function and research advance of NuMA protein
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摘要 NuMA存在于动、植物细胞中,是细胞核基质的重要组成部分,参与纺锤体极的组装与分解、核重组等过程,调节细胞周期,对细胞的有丝分裂和减数分裂具有重要作用。此外,对细胞凋亡也发挥重要作用,NuMA的降解是早期细胞调亡的标志。 Protein NuMA resides in animal and plant cells. It is an important component of the nuclear matrix, NuMA is involved in the spindle pole assembly and disassembly, nuclear reformation and cell cycle regulation. NuMA plays an essential role in the mitosis and meiosis. In addition, NuMA produces a marked effect in cell apoptosis. NuMA cleavage has been used as a early marker of cell apoptosis.
作者 杨立琳 孙露双 曾晓 曹允考
机构地区 东北农业大学动物医学学院
出处 《东北农业大学学报》 CAS CSCD 2008年第10期127-130,共4页 Journal of Northeast Agricultural University
关键词 NUMA 细胞 功能 NuMA cell function
分类号 R329.1 [医药卫生—人体解剖和组织胚胎学]
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参考文献17

  • 1Gobert G N, Hueser C N, Curran E M, et al. Immunolocalization of NuMA and phosphorylated proteins during the cell cycle in human breast and prostate cancer ceils as analyzed by immunofluorescence and postembedding immunoelectron microscopy [J]. Histochem Cell Biol, 2001, 115: 381-395.
  • 2Gehmlich K, Haren L, Merdes A. Cyclin B degradation leads to NuMA release from dynein/dynactin and from spindle poles [J]. EMBO Rep, 2004(5): 97-103.
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同被引文献19

  • 1Compton DA et al. NuMA is required for the proper completion of mitosis. J Cell Biol, 1993, 120:947-957.
  • 2Gehmlich K et al. Cyclin B degradation leads to NuMA release from dynein/dynactin and from spindle poles. EMBO Rep, 2004, 5:97-103.
  • 3Dai Yet al. Fate of centrosomes following somatic cell nuclear transfer (SCNT) in bovine oocytes. Reproductian, 2006, 131: 1051-1061.
  • 4Liu Z et al. The nuclear mitotic apparatus (NuMA) protein is contributed by the donor cell nucleus in cloned porcine embryos. Front Biosci, 2006, 11:1945-1957.
  • 5Yah LY et al. NuMA distribution and microtubule configuration in rabbit oocytes and cloned embryos. Reproduction, 2006, 132:869-876.
  • 6Van Thuan N et al. Donor centrosome regulation of initial spindle formation in mouse somatic cell nuclear transfer: roles of 7-tubulin and nuclear mitotic apparatus protein 1. Biol Reprod, 2006, 74:777-787.
  • 7Moreira PN et al. Architectural defects in pronuclei of mouse nuclear transplant embryos. J Cell Sci, 2003, 116:3713-3720.
  • 8Zhong ZS et al. Function of donor cell centrosome in intraspecies and interspecies nuclear transfer embryos, Exp Cell Res, 2005, 306:35-46.
  • 9Simerly C et al. Embryogenesis and blastocyst development after somatic cell nuclear transfer in nonhuman primates: overcoming defects caused by meiotic spindle extraction. Dev Biol, 2004, 276:237-252.
  • 10Yan LY et al. Dynamic changes in NuMA and microtubules in monkey-rabbit nuclear transfer embryos. Front Biosci, 2006, 11:1892-1900.

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东北农业大学学报
2008年 第10期

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