氟康唑片与达克宁栓治疗念珠菌性阴道炎的药物经济学分析

Pharmacoeconomic Analysis of Fluconazole Tablets and Miconazole Suppository in Treatment of Candidal Vaginitis

目的比较氟康唑片口服与达克宁栓治疗念珠菌性阴道炎的成本-效果。方法将78例念珠菌性阴道炎患者随机分为治疗组和对照组,分别给予氟康唑片(40例)和达克宁栓(38例)治疗,并用药物经济学原理进行成本-效果分析。结果治疗两周后治疗组和对照组总有效率(治愈+显效)分别为95.00%和81.58%,成本-效果比分别为7.47和24.27。但两组要达到相同或相似的治疗效果,达克宁栓的费用是氟康唑的3.25倍,不良反应发生率均轻微。结论氟康唑片口服治疗念珠菌性阴道炎安全有效,经济学评价效果优于达克宁栓。

Objective To compare the cost-effectiveness of Fluconazole Tablets and Miconazole Suppository in the treatment of candidal vaginitis. Methods Seventy-eight patients were randomly divided into therapeutic group （n =40）, treated with Fluconazole Tablet orally and control group （n =38） treated with Miconazole Suppository via vagina. The analysis of cost-effectiveness of two therapeutic schemes was performed by pharmacoeconomic principle. Results The curative effects （cure ＋excellence） were 95.00% and 81.58%, respectively, in two groups, after two week＇s treatment. The cost-effectiveness ratio was 7.47 and 24. 27, respectively. In order to reach the same therapeutic efficacy, the cost in the control group was 3.25 times higher than that of the therapeutic group, the adverse effect incidence rate was light. Conclusion Fluconazole Tablets for Treating candidal vaginitis is safe and effective, and the economic evaluation effect is superior to that of Miconazole Suppository