降糖防聋胶囊干预糖尿病性聋动物模型的实验研究

Effect of Jiangtangfanglong capsule on hearing impairment in deaf diabetes animal models

目的探讨降糖防聋胶囊对实验性糖尿病性聋动物模型听力的影响。方法Wistar大鼠40只,腹腔一次注射55mg/kg链脲佐菌素(STZ)建立实验性糖尿病性聋动物模型。随机分为2组,治疗组20只给予降糖防聋胶囊混悬液10g.kg-1.d-1灌服。对照组20只给予等量生理盐水,2组分别在成模后1、2、3个月接受听力脑干反应(ABR)检测。结果治疗1个月后,2组ABR波潜伏期及波间期相比无明显差异(P>0.05),治疗2、3个月后,治疗组较对照组ABR波潜伏期及波间期均有明显缩短,差异有统计学意义(P<0.05,P<0.01)。结论降糖防聋胶囊对糖尿病性聋动物模型的听力具有防治作用。

Objective To observe the effect of Jiangtangfanglong capsule on hearing impairment in deaf diabetes animal models.Method 40 Wistar rats with experimental deaf diabetes, induced by 55 mg/kg streptozotocin once intraperitoncally, were randomly divided into treatment group （ n = 20） and control group （ n = 20） .The treatment group was administered Jiangtangfanglong capsule （10 g· kg^-1· d^-1 ）, and the control group was given equal volume saline in same way. After 1, 2 and 3 months, auditory brainstem response（ABR） of the two groups were detected respectively. Results The latencies and interphase of ABR waves after 1 month treatment in the two group was not changed （ P 〉 0.05）. The results in the treatment group were shortened after 2 or 3 months treatment with a significant difference compared with the control group （ P 〈 0.05 or P 〈 0. 01 ）. Conclusion Jiangtangfanglong capsule can prevent hearing impairment in deaf diabetes animals.