摘要
目的探讨胺碘酮对室性早搏和心率变异(HRV)的影响。方法用动态心电图时域分析法对61例室性早搏患者在胺碘酮治疗前、后心率变异性各项指标进行检测,并与对照组67例进行疗效比较。结果与对照组比较,代表心率总变异程度的SDNN、SDANNI和SDNNI差异有统计学意义(P<0.01),代表迷走神经功能指标的YMSSD、PNN50差异也有统计学意义(P<0.05)。胺碘酮组用药后与用药前比较,对室性早搏有效率为68%,SDNNI、SDANNI、rMSSD和PNN50均有所升高(P<0.05)。结论胺碘酮不但能减少室性早搏,改善症状,而且能提高心率变异性,改善预后。
Objective To explore the clinical effects of amiedarone on ventricular premature beat （VPB）. Methods The different in-dex of the heart rate variability （HRV） in 61 eases with VPB was observed by means of 24 h ambulatory ECG before and after use of amiodarone and that in other 67 cases with VPB as control. Results After therapy of amiodarone, SDNN, SDANNI, and SDNNI that represented to talHRV and rMSSD and pNN50 that represented vagal function decreased（P〈0.01 and P〈0.05,respeetively）, compared with the control group.The VPB descended by 68% after therapy and SDNN, SDANNI, SDNNI,rMSS and pNN50 of HRV all reduced （P〈0.05）. Conclusion Amiodarone can not only reduce the VPB and change symptoms,but also increase HRV and improve prognosis.
出处
《中国心血管病研究》
CAS
2008年第11期826-827,共2页
Chinese Journal of Cardiovascular Research
关键词
胺碘酮
室性早搏
心率变异
Amiodarone
Ventricular premature beart
Heart rate variability
