黄体功能不全不孕、不育与免疫功能障碍

Study on relationship between infertility due to luteal deficiency and immunodeficiency

８２例黄体功能不全患者，用简化中药人工周期加人绒毛膜促性腺激素治疗后，随访５～１０年，结果５３例患者共妊娠５８例次，２９例治疗后随访５～１０年未孕。根据随访结果，对已孕（Ａ组）和未孕（Ｂ组）患者的免疫功能进行回顾性分析，结果显示：ＣＤ４、ＣＤ８均值，ＣＤ４／ＣＤ８比值，两组患者有显著差异（Ｐ＜０．０１），提示ＣＤ４均值、ＣＤ４／ＣＤ８比值下降，ＣＤ８上升可能是黄体功能不全久治不愈的重要原因之一。

Objectives: To study the relationship between infertility due to luteal deficiency and immunodeficiency.Design: Clinical and laboratory studies.Setting: Second Affiliated Hospital,Jiangxi Medical College.Subjects: 82 patients with luteal deficiency.Methods: Total B lymphocytes(CD20),total T lymphocytes(CD3),Thelper cells (CD4)and Tsuppressor cells (CD8)were measured with the indirect immunofluorescent method.Patients were treated with simplified artificial cycle by traditional Chinese medicine combined with human chorionic gonadotropin.They were followedup for 5～10 years.Results: Among the 82 patients,53 patients had 58 pregnancy altogether.The difference was remarkable between the pregnancy (A group) and infertile patients(B group) by comparing the mean rate of CD4,CD8 and the ratio of CD4/CD8 (P<0.01). The mean rate of CD4,and the ratio of CD4/CD8 of the patients in B group were remarkably lower than those in A group,while the mean rate of CD8 were remarkably higher than that in A group.Conclusion: The mean rate of CD4,the ratio of CD4/CD8 decrease,the mean rate of the CD8 rises,is possible to be one of the important factors for failure of treatment in luteal dificient patients.