儿茶酚氧位甲基转移酶基因与注意缺陷多动障碍患儿认知功能的关联研究

Association study of catechol-O-methyitransferase gene polymorphism and cognitive function in children with attention deficit hyperactivity disorder in China

目的探讨儿茶酚氧位甲基转移酶（COMT）基因Val108／158Met（rs4680）多态性对注意缺陷多动障碍（ADHD）患儿认知功能的影响。方法对203例中国汉族ADHD患儿进行韦氏记忆测查、Stroop测验及数字划消测查，评定记忆力、反应抑制能力和注意力，并检测COMT基因Val158Met多态性。按照基因型将样本分为高活性基因型组（92例，ValVal）和中低活性基因型组（111例，ValMet和MetMet），比较两组间各项测查结果的异同。结果高活性基因型组图片分测验[（11．7±3．1）分]和Stroop测验C部分错误数（0个）的成绩好于中低活性基因型组[分别为（10．8±2．9）分和1个；P〈0．05～0．01]。两组其他方面的差异均无统计学意义。结论COMT基因Val158Met多态性与ADHD患儿的认知功能中的记忆力、反应抑制能力和注意力相关。

Objective To investigate the association of catechol-O-methyltransferase （COMT） gene Val108/158Met SNP （rs4680）with cognitive function in children with attention deficit hyperactivity disorder （ADHD） in China. Methods A total of 203 DSM-Ⅳ ADHD children of Chinese Han descent were included, both the data of neuropsychological tests （ Wechsler Memory Scale, Stroop test and cancellation test） and COMT Val108/158Met genotyping results were obtained. The two-sample t test and Mann-Whitney test were used to compare the average scores between two groups defined by COMT Val158Met genotypes, high-enzymatic activity （ ValVal, n = 92） and mid-low enzymatic activity （ ValMet and MetMet, n = 111 ）. Results The children with high-enzymatic activity （ValVal） performed significantly better on some aspects of Wechsler Memory Scale and Stroop test （picture recall, and part C error number in Stroop test） than those with mid-low enzymatic activity （ P 〈 0. 05-0. 01 ）. No statistically significant differences were found between two groups and index in other tests. Conclusion The results suggest that COMT gene Val108/158Met polymorphism may be related to the cognitive functions as memory, response inhibition and attention in ADHD children in China.