非酒精性血清丙氨酸氨基转移酶升高与代谢参数的相关性分析

Relationship between increased serum activity of alanine aminotransferase and metabolic parameters in non-alcoholic population

目的分析中国北方汉族人群非酒精性血清ALT水平升高与各代谢参数的相关性。方法将5351名在清华大学玉泉医院体检的受试者根据ALT升高与否（940U／L）分为两组，比较两组间各代谢组分的差异。结果体重指数（BMI）、收缩压、舒张压、甘油三酯、总胆固醇、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDL—C）及空腹血糖（FBG）水平在ALT升高组与对照组问差异有统计学意义。男性ALT升高与舒张压有关，而女性与收缩压有关。logistic回归分析结果表明，ALT升高与男性、BMI、甘油三酯、总胆固醇和FBG水平升高、LDL—C水平降低和年龄较低有关。结论在中国北方汉族人群中，肥胖、高血压、高血脂、高血糖等代谢紊乱与非酒精性ALT升高有关。

Objective The aim of this study is to identify association between increased serum activity of alanine aminotransferase （ALT） and metabolic parameters in non-alcoholic population of north China. Methods A total of 5351 subjects who came to visit Yuquan Hospital of Tsinghua University for health examinations during May to December 2007 were divided into two groups based on their serum ALT activities, one with equal to or more than 40 U/L and the other with less than 40. Anthropometrie data, blood pressure, serum ALT, serum levels of tfiglyeeride （TG）, total cholesterol （TC）, high-dense lipoprotein-cholesterol （HDL-C）, low-dense lipoprotein-eholesterol （LDL-C） and fasting blood glucose （FBG） were measured for all of them. Results Body mass index （ BMI）, systolic blood pressure （ SBP）, diastolic blood pressure （ DBP）, TG, TC, HDL-C, LDL-C and FBG were significantly different between the two groups. BMI, TG, TC, HDL-C, LDL-C and FBG all associated with increased ALT both in males and females. DBP associated with increased ALT in males and SBP with it in females. Logistic regression analysis showed that male, younger age, raised BMI, TG, TC, FBG and reduced HDL-C were strongly associated with increased serum ALT. Conclusions Results showed that metabolic disturbance such as obesity, hypertension, dyslipidemia, hyperglycemia, and so on associated with increased ALT in nonalcoholic population of north China.