利培酮治疗以阳性症状为主的首发女性精神分裂症患者EEM研究

Case-control studies of EEM changes after risperidone treatment in first-episode female schizophrenic patients with positive symptoms

目的探讨利培酮治疗以阳性症状为主的首发女性精神分裂症患者的探查性眼球活动,为电生理指标在精神科临床的应用提供依据。方法将44例以阳性症状为主的首发女性精神分裂症患者设为研究组,口服利培酮治疗,观察6w,于治疗前及治疗6w末采用阳性与阴性症状评定量表评定患者的精神症状,同时进行探究性眼动分析,测定眼球运动注视点数和反应性探索分;同期随机抽取40例健康体检女性设为对照组,测定眼球运动注视点数和反应性探索分,并与研究组测定结果进行对比分析。结果研究组治疗6w末,阳性与阴性症状量表评分阳性症状分、阴性症状分及总分均较治疗前有显著下降(P<0.01),治疗前后眼球运动注视点数及反应性探索分均显著低于对照组(P均<0.01),但治疗6w末眼球运动注视点数及反应性探索分均显著高于治疗前(P均<0.01)。结论首发女性精神分裂症患者发作期存在明显探查性眼球活动的病理改变,探查性眼球活动异常是首发精神分裂症较特异的生物学标志。随着临床症状的缓解,探查性眼球活动获得部分改善。

Objectives To explore electrophysiologic examination of cognitive function of the first-episode female schizophrenics using exploratory eye movement （EEM）. Methods 44 first-episode female schizophrenics（study group） were treated with oral risperidone and observed for 6 weeks. Scale for the assessment of positive and negative symptoms（SAPS and SANS） were used to evaluate the psychiatric symptoms and EEM to NEF and RSS. 40 healthy women were controllers. Results Compared with pre-treatment, the scores of PAPS, PANS and total decreased obviously at the end of the 6th week of treatment in the study group（P〈0.01）. NEF and RSS scores of EEM in study group both pre-and post-treatment were significantly lower than those in control group（P〈0.01）. NEF and RSS scores at the end of the 6＇h week were higher than those before treatment in study group（P〈0.01）. Conclusion The first-episode female schizophrenia patients exist conspicuous pathological changes on EEM during the period of onset, and EEM improves partially with the relief of clinic symptoms after risperidone treatment. EEM can be a biological index for first-episode schizophrenia.