期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

MAPK信号转导通路与肾纤维化 被引量：5

原文传递
导出
摘要 肾纤维化是各种原发和继发性肾脏病进展到终末期肾衰（end -stage renal disease,ESRD）的基本病理过程，明确其发病机制以减缓乃至阻断其进展是研究的难点、热点所在。近年来，越来越多的证据表明，丝裂原活化蛋白激酶（mitogen—activated protein kinase，MAPK）信号转导通路与肾纤维化关系密切。本文就二者关系作一综述。
作者 黄陈招(综述) 朱彩凤(审校) 朱斌(审校)
机构地区 浙江中医药大学附属第二医院杭州市中医院肾病科
出处 《国际泌尿系统杂志》 2008年第6期829-833,共5页 International Journal of Urology and Nephrology
基金 浙江省杭州市卫生局重点项目200520070
关键词 纤维变性 肾疾病 信号传递
分类号 R692.32 [医药卫生—泌尿科学]
  • 相关文献

参考文献22

  • 1王秋月,佟健华,杜娟,赵宏,陆娇薇.TGF-β1通过p38MAPK信号通路调控肾小球系膜细胞分泌纤维连接蛋白的研究[J].中国医科大学学报,2006,35(3):246-248. 被引量：14
  • 2Jiang T, Che Q, Lin Y,et al. Aldose reductase regulates TGF -beta1- induced production of fibronectin and type Ⅳ collagen in cultured rat mesangial cells. Nephrology (Carlton) ,2006,11 ( 2 ) : 105 - 112.
  • 3Rodriguez- Barbero A, Dorado F, Velasco S,et al. TGF-beta1 induces COX - 2 expression and PGE2 synthesis through MAPK and PI3 K pathways in human mesangial ceils. Kidney Int, 2006,70 (5) : 901 - 909.
  • 4Liu S, Liang Y, Huang H, et al. ERK - dependent signaling pathway and transcriptional factor Ets - 1 regulate matrix metalloproteinase - 9 production in transforming growth factor - beta1 stimulated glomerular podoeytes. Cell Physiol Biochem ,2005,16 (4 - 6 ) : 207 - 216.
  • 5Kim SI, Kwak JH, Zachariah M, et al. TGF - beta - activated kinase 1 and TAK1 - binding protein 1 cooperate to mediate TGF - beta1 - induced MKIO - p38 MAPK activation and stimulation of type Ⅰ collagen. Am J Physiol Renal Physiol,2007,292 ( 5 ) : 1471 - 1478.
  • 6Lai XX, Ding GH, Huang CX, et al. Angiotensin Ⅱ- induced podocyte apoptosis: role of the MAPK subtypes. Beijing Da Xue Xue Bao, 2004,36(2) :131 - 134.
  • 7娄宁,余学清,祝胜郎,郑勋华,董秀清.血管紧张素Ⅱ激活巨噬细胞株p38MAPK信号通路并诱导其增殖[J].中国免疫学杂志,2005,21(6):416-420. 被引量：7
  • 8Kaneshiro Y, Ichihara A, Sakoda M ,, et al. Slowly progressive, angiotensin 11 -independent glomerulosclerosis in human (pro)renin receptor - transgenic rats. J Am Soc Nephrol, 2007,18 ( 6 ) : 1789 - 1795.
  • 9Kang YS, Park YG, Kim BK, et al. Angiotensin Ⅱ stimulates the synthesis of vascular endothelial growth factor through the p38 mitogen activated protein kinase pathway in cultured mouse podocytcs. J Mol Endoerinol,2006,36(2) :377 -388.
  • 10Bai Y, Wang L, Li Y, et al. High ambient glucose levels modulates the production of MMP - 9 and alpha5 (Ⅳ) collagen by cultured podocytes. Cell Physiol Biochem,2006,17 ( 1 - 2 ) :57 - 68.

二级参考文献31

  • 1Suzuki Y, Ruiz-Ortega M, Loenzo O et al. Inflammation and angiotensin Ⅱ [J].Int J Biochem Cell Biol,2003;35(6):881-900.
  • 2Guo G, Morrissey J, McCraken R et al. Contributions of angiotensin Ⅱand tumor necrosis factor-alpha to the development of renal fibrosis [J].Am J Physiol Renal Physiol,2001 ;280(5): F777-F785.
  • 3Yu X Q, Wu L L, Huang X R et al. Osteopontin expression in progressive renal injury in remnant kidney: role of angiotensin Ⅱ [J]. Kidney Int,2000;58(4): 1469-1480.
  • 4Eddy A A. Molecular basis of renal fibrosis [J]. Pediatr Nephrol,2000;15(3-4) :290-301.
  • 5Ruiz-Ortega M, Ruperez M, Loenzo O et al. Angiotensin Ⅱ regulates the synthesis of proinflammatory cytokines and chemokines in the kidney [J].Kidney Int,2002;Suppl(82): 12-18.
  • 6Wada T, Furuichi K, Sakai N et al. Involvement of p38 mitogen-activated protein kinase followed by chemokine expression in crescentic glomerulonephritis [J]. Am J Kidney Dis,2001 ;38(6): 1169-1177.
  • 7Ono K, Han J. The p38 signal transduction pathway: activation and function [J]. Cell Signal, 2000; 12( 1 ): 1-13.
  • 8Luft F C. Workshop:mechanisms and cardiovascular damage in hypertension [J]. Hypertension, 2001; 37(2 part2): 594-598.
  • 9Takeuchi K. Signal transduction systems of angiotensin Ⅱ receptors [J].Nippon Rinsho, 1999;57(5): 1070-1077.
  • 10Tian W, Zhang Z, Cohen D M. MAPK signaling and the kidney [J].Am J Physiol Renal Physiol,2000;279(4):F593-F604.

共引文献28

同被引文献75

引证文献5

二级引证文献51

国际泌尿系统杂志
2008年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部