米非司酮、双炔失碳酯及宫内节育器用于紧急避孕临床效果观察

Clinical study of mifepristone, A nordrin and intrauterine device used for emergency contraception

对８４名月经规律的正常妇女在避孕失败或无保护性交后要求紧急避孕者，按本人意愿分为３组：Ａ组（ｎ＝２４）于性交次日开始服米非司酮２５ｍｇ／１２ｈ、２天，共１００ｍｇ；Ｂ组（ｎ＝３０）性交次晨服双炔失碳酯７．５ｍｇ，１２小时后再服７．５ｍｇ，以后每晚服７．５ｍｇ，连服１０天，共９０ｍｇ；Ｃ组（ｎ＝３０）于性交后１２０小时内放置宫内节育器（ＩＵＤ）Ｍｕｌｔｉｌｏａｄ（ＭＩ）Ｃｕ３７５。结果：Ａ及Ｃ组无一例妊娠，成功率１００％，Ｂ组妊娠２例，成功率９３％。主要的副反应是恶心、呕吐等胃肠反应，均在Ｂ组出现，而月经改变以Ｂ及Ｃ组为多见。认为，米非司酮的效果优于双炔失碳酯；ＩＵＤ在排除了生殖道感染的妇女中使用，能取得满意的效果。

Objectives: To study the efficacy of mifepristone A nordrin and intrauterine device (IUD) used for emergency contraception. Design: A non randomized clinical study. Setting: Department of Family Planning of Yunnan Provincial Hospital in Kunming. Subject: 84 normal women with unprotected intercourse or contraception failure were oberserved during (October 1993 and January 1996). Methods: Women were allocated into 3 groups by their own choice.In group A( n =24),mifepristone was given 25 mg q12 h×2 days.In group B( n =30),A nordrin was given 7.5 mg in the morning after the intercourse, repeated once again 12 hours later,followed by 7.5 mg qd×10 dqys.Group C( n =30),Multiload Cu375 IUD was inserted within five days of the intercourse. Results: The contraceptive effective rates were 100% in both group A and C,and 93% in group B.The main side effects including nausea and vomiting occurred frequently in group B,menstrual changes occurred frequent in group B and C. Conclusion: For emergency contraception,mifepristone was more effectives than A nordrin,while IUD was good for women who have no reproductive tract infection.