靶向细胞周期蛋白B1的抗肿瘤研究

Study in Targeting to Cyclin B1 against Malignant Tumors

细胞周期蛋白B1(cyclin B1,CCNB1)是有丝分裂期(M期)周期蛋白,与细胞周期蛋白依赖性激酶1(cyclin-dependent kinase 1,CDK1)结合形成成熟促进因子(maturation promoting factor,MPF),MPF的激活为真核细胞启动有丝分裂所必需。CCNB1在肿瘤组织中普遍高表达,该蛋白质作为一种细胞周期进程调节剂在肿瘤细胞内的表达量是判断肿瘤恶性程度高低的指标之一,被视为肿瘤抗原,故靶向CCNB1进行抗肿瘤治疗是肿瘤基因治疗中一个极有潜力的策略。首先分析了CCNB1与肿瘤的相关性,进而从CCNB1活性抑制因子、药物或化合物对CCNB1的抑制作用及CCNB1与抗肿瘤免疫等多方面对靶向CCNB1的抗肿瘤研究进行了综述。

Cyclin B 1 （CCNB 1） is the regulatory subunit of the cdc2 serine/threonine kinase （mitotic promoting factor, MPF）, and accumulation of CCNB 1 in late G2 phase of the cell cycle is a prerequisite for mitotic initiation in mammalian cells. In addition, CCNB 1 is overexpressed in various tumor types and plays important roles in cancer development, and was identified a new tumor antigen. Therefore, a potential strategy for cancer gene therapy is to suppress the expression and/or activity of CCNB 1 by various methods. This paper reviews the recent advances of anti-tumor research in the field of inhibitting CCNB 1.