肌细胞增强因子2在心力衰竭过程中的作用

The Effects of Myocyte Enhancer Factor 2 on the Process of Heart Failure

心脏在长期过量负荷及神经体液系统过度激活的影响下,可发生以心肌细胞肥大、心肌纤维排列紊乱、心肌间质细胞增生及胚胎基因再表达增加为主的病理改变,从而引起心脏泵功能减退、心室扩张、心室肥厚和纤维化,最终导致心力衰竭。肌细胞增强因子2(myocyte enhancer factor 2,MEF2)是一种特定的转录因子,其主要功能是促进肌细胞分化过程中的基因转录,在骨骼肌、心肌、平滑肌的发育过程中起介导细胞分化的作用。近年来的研究发现,在心力衰竭过程中,MEF2提供了心室重构信号转导过程中的作用靶点,可能参与了心室肥厚与心力衰竭的过程。

Many factors such as long time of workload or excessive nerrohumoral signaling system, can activate a pathological response characterized by hypertrophic growth of cardiaomyocytes, rearrangment of myocyte, increased deposition of extracellular matrix （ECM） proteins and reactivation of fetal cardiac genes. All the above abnormalities will cause pump dysfunction, chamber dilation, myocyte hypertrophy and myocardial fibrosis in the heart and therefore lead to heart failure gradually. MEF2 are specific transcription factors, of which the main function is to control the transcription of genes in muscle differentiation, therefore mediate differentiation during the development of skeletal, cardiac and smooth muscle. Recently, MEF2 are shown to participate in the process of myocyte hypertrophy and heart failure, and may provide a new target for the signal pathways during cardiac remodeling.