儿童白血病全身分割放射治疗的临床研究

Fractionated total body irradiation in the treatment of childhood acute lymphoblastic leukemia

目的观察在未行全身麻醉的情况下白血病患儿接受全身分割放射治疗的可行性,及患儿在异基因骨髓移植过程中与放射治疗有关的早期和晚期的毒性反应情况。方法对8例高危复发的急性淋巴细胞性白血病(ALL)患儿进行全身分割放射治疗,作为异基因骨髓移植的预处理方法。结果8例患儿均能顺利完成全身分割放射治疗,早期急性反应轻微。经3年以上随访,3年存活率为37.5%。结论儿童患者对全身分割放射治疗有良好的耐受性,可作为异基因骨髓移植的重要预处理手段而在临床广泛应用。

Objectives To evaluate the possibility of fractionated total body irradiation （TBI） in the treatment of acute lymphoblastic leukemia （ALL） of pediatiic patients without anaesthetization, and explore the acute side effects and late toxicities of TBI in the course of allogeneie bone marrow transplantation. Methods Fractionated TBI were performed in 8 pediatric patients with ALL as preparative cytoreduetive regimens for bone marrow transplantation. Results All pediatric patients were successfully complete the fractionated TBI, and the acute side effects were low. Three-year-survival rates was 37% （3/8）. Conclusions The pediatric patients have satisfactory tolerance with the fractionated TBI, The fractionated TBI without anaesthetization could a major component in preparative regimen for allogeneie hone marrow transplantation in the treatment of ALL in children.