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系统性红斑狼疮患儿PD-1分子的表达 被引量：1

Expression of PD-1 on peripheral blood lymphocyte in systemic lupus erythematosus patients
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摘要 目的研究PD-1分子的表达与系统性红斑狼疮(SLE)的发病机制及病情的关系。方法应用流式细胞仪检测各期SLE患儿(活动期、缓解期)外周血CD3+、CD4+、CD8+T细胞上PD-1分子的表达。结果在各期SLE患儿中外周血CD3+、CD4+、CD8+淋巴细胞上PD-1分子的表达均明显高于正常对照(P<0.05)。结论在系统性红斑狼疮患儿外周血淋巴细胞上PD-1分子表达明显高于正常,各组SLE患儿存在B淋巴细胞的异常增殖,推测PD-1通路在SLE的免疫病理中发挥重要作用。 Objectives To investigate the role of PD-1 in pathogenesis of patients with systemic lupus erythematosus （SLE） . Methods Flow cytometjry was used to determine expression of PD-1 on peripheral blood lymphocyte in SLE patients （include active stage group and catabasis group）. Results Expression of PD-1 on peripheral blood lymphocyte in both SLE patient groups are significantly higher than that in health control （P 〈 0.05）. Conclusions Expression of PD-1 on peripheral blood lymphocyte in SLE patients are obviously higher than that in health control, and B cells abnormally generate in SLE children. We asume that PD-1 pathway may play an important role in immunopathogenesis of SLE patients.
作者 夏敏 薛海燕 曹兰芳
机构地区 上海交通大学医学院附属仁济医院儿科
出处 《临床儿科杂志》 CAS CSCD 北大核心 2008年第11期959-961,共3页 Journal of Clinical Pediatrics
基金 上海市科学技术委员会科研计划项目(No.044119716)
关键词 PD-1分子 系统性红斑狼疮 儿童 PD-1 systemic lupus erythematosus children
分类号 R725.9 [医药卫生—儿科]
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参考文献11

  • 1Freeman GJ, Long AJ, Iwai Y, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation [J]. J Exp Med ,2000, 192(9) : 1027-1034.
  • 2Latchman YE, Liang SC, Wu Y, et al. PD-L1-deficient mice show that PD-L1 on T cells,antigen-presenting cells: and host tissues negatively regulates T cells [J]. Proc Natl Acad Sci USA,2004,101 (29) : 10691-10696.
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临床儿科杂志
2008年 第11期

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