肝癌转移研究的问题与展望
摘要
众所周知,肝癌是病死率较高的恶性肿瘤,5年生存率较低。当前肝癌临床治疗的研究十分活跃,除手术、放射治疗、化学治疗和生物治疗外,又出现了局部治疗、肝移植、靶向治疗等新疗法。但所有的治疗方法几乎均面临着治疗后转移复发这个问题。我们开展较早的小肝癌局部切除,其5年生存率在最近的20年停留在50%~60%,未见进一步提高。肝癌肝移植由于免疫抑制剂的应用,使转移复发问题更为复杂。
出处
《中华外科杂志》
CAS
CSCD
北大核心
2008年第21期1601-1601,共1页
Chinese Journal of Surgery
参考文献8
-
1Qin LX, Tang ZY, Sham JS, et al. The association of chromosome 8p deletion and tumor metastasis in human hepatocellular carcinoma. Cancer Res, 1999,59:5662-5665.
-
2Ye QH, Qin LX, Forgues M, et al. Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med,2003,9:416- 423,
-
3Budhu A, Forgues M, Ye QH, et al. Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell,2006,10:99-111.
-
4Pang JZ, Qin LX, Ren N,et al. Loss of heterozygosity at D8S298 is a predictor for long-term survival of patients with tumor-node-metastasis stage I of hepatocellular carcinoma. Clin Cancer Res, 2007,13:7363-7369.
-
5Ding SJ, Li Y, Tan YX,et al. From proteomic analysis to clinical significance: overexpression of cytokeratin 19 correlates with hepatocellular carcinoma metastasis. Mol Cell Proteomics, 2004, 3:73-81.
-
6Zhang T, Sun HC, Xu Y, et al. Overexpression of platelet-derived growth factor receptor alpha in endothelial cells of hepatocellular carcinoma associated with high metastatic potential. Clin Cancer Res,2005,11:8557-8563.
-
7Wang L, Tang ZY, Qin LX, et ol. High-dose and long-term therapy with interferon-alfa inhibits tumor growth and recurrence in nude mice bearing human hepatocellular carcinoma xenografts with high metastatic potential. Hepatology, 2000,32:43 -48.
-
8Yamashita T, Forgues M, Wang W, et al. EpCAM and alpha- fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res ,2008,68 : 1451-1461.
-
1袁可淼,尤建良.晚期胃癌的中西医结合治疗新进展[J].辽宁中医药大学学报,2011,13(1):209-211. 被引量:15
-
2王尧,徐农.晚期胃癌内科治疗问题与展望[J].实用肿瘤杂志,2015,30(5):404-408. 被引量:4
-
3李忠武,曹登峰.胃癌病理分型与临床个体化治疗——问题与展望[J].中国医学前沿杂志(电子版),2012,4(5):15-20. 被引量:6
-
4朱慰祺.直肠癌根治术后的局部复发问题[J].中国实用外科杂志,1995,15(12):717-719. 被引量:13
-
5廖大勇,董浩,张栋林.术前血清CEA水平对结直肠癌术后复发的预测价值[J].四川医学,2014,35(4):459-461. 被引量:1
-
6秦新裕,刘凤林.胃肠癌术后复发的外科治疗[J].中华胃肠外科杂志,2006,9(3):193-196. 被引量:8
-
7高红强,李立.siRNA治疗原发性肝癌研究进展[J].中国社区医师(医学专业),2012,14(7):10-11.
-
8李仕来,黎乐群.经导管肝动脉化疗栓塞术在肝细胞癌中的治疗进展[J].医学综述,2015,21(17):3126-3129. 被引量:11
-
9王会忠,冉飞武,梁超前.泰素帝治疗转移性乳腺癌的研究现状[J].中国肿瘤临床与康复,2004,11(6):555-557.
-
10魏宪义.流感嗜血杆菌实验室诊断存在的问题与展望[J].中国公共卫生,2000,16(1):77-79. 被引量:3