非酒精性脂肪性肝病患者血清硫氧还蛋白、铁蛋白、瘦素水平测定

Correlation of nonalcoholic fatty liver with serum thioredoxin,serum ferritin,and serum leptin

目的研究血清硫氧还蛋白(TRx)、铁蛋白(Fer)、瘦素(Lep)与非酒精性脂肪性肝病的关系。方法应用全自动生化分析仪检测ALT、AST,放射免疫法和ELISA法检测Lep、Fer、TRX。结果非酒精性脂肪性肝病组中TRX、Fer、Lep高于对照组,TRX、Fer、Lep检测值在NASH组中分别为[(66.18±20.96)ng/mL、(350.56±47.06)ng/mL、(16.57±6.88)ng/mL],单纯性脂肪肝组中[(35.72±8.68)ng/mL、(163.98±39.41)ng/mL、(7.68±5.14)ng/mL],正常对照组中[(25.53±6.59)ng/mL、(117.40±31.43)ng/mL、(5.49±4.08)ng/mL]。结论联合动态监测ALT、AST、TRX、Fer、Lep有助于判断肝脏炎症及纤维化状况。

Objective To study the correlation of nonalcoholic fatty liver （NAFL） with serum Thioredoxin （TRX）, serum ferritin （Fer）, and serum leptin （Lep）. Methods The levels of alanine transferase （ALT） and aspartate aminotransferase （AST） were measured with automatic biochemistry analyzer. The serum levels of Lep and Fer were detected by radioimmunoassay, while the serum TRX level was measured by using enzyme-linked immunosorbent assay （ELISA）. Results Compare to the control group, the serum levels of TRX, ferritin, and leptin were obviously high in patients with NAFL. Conclusion The dynamic changes of ALT, TRX, Fer, and Lep can be used to evaluate the stage of hepatitis and hepatic fibrosis.