复方樟柳碱在中老年眼肌麻痹治疗中的应用

Compound anisodine in treatment of elderly ophthalmoplegia

目的观察复方樟柳碱治疗中老年眼肌麻痹的效果,旨在寻找其治疗的有效手段。方法将52例(52眼)自2006年1月至2007年6月来我院就诊的眼肌麻痹患者按就诊顺序随机分成复方樟柳碱组27例,扩血管药物对照组25例。复方樟柳碱组:复方樟柳碱2 mL患侧颞浅动脉旁皮下注射,每天1次,每疗程14 d,可连续注射4个疗程;对照组:采用激素、血管扩张剂治疗14～60 d。全部患者同时给予大剂量VitC、VitB1、VitB12及能量合剂。结果复方樟柳碱组总有效率85.2%;对照组总有效率52.0%.2组比较结果显示:复方樟柳碱组疗效明显优于对照组,差异有显著统计学意义(χ2=6.71,P<0.01)。结论复方樟柳碱治疗中老年眼肌麻痹疗效显著,治疗方便,而且是较理想的治疗手段。

Objective To evaluate the effects of compound anisodine in the treatment of the elderly patients with ophthalmoplegia, aiming to seek for the valid means of its treatment. Methods From January 2006 to June 2007,52 cases （ 52 eyes） of ophthalmoplegia in the elderly were randomly divided into compound anisodine group （ 27 cases） and vasodilator control group （25 cases）. The compound anisodine group was treated with temporal hypodermic injection of 2 mL compound anisodine, once a day, 14 days a course for 4 courses. And the vasodilator control group was treated with vascular dilator for 14 days to 60 days. All cases were appended massive dosage Vitamin C, Vitamin B,, Vitamin B12 and energy mixture （ATP CoA etc. ）. Results The total efficiency was 85. 2% in compound anisodine group, 52.0% in the control group. Valid rate of the compound anisodine group was higher than that of the vasodilator control group, and the difference between the two groups was remarkably significant（χ^2 = 6.71, P 〈 0.01 ）. Conclusion Compound anisodine is effective, convenient and ideal in the treatment of elderly people with ophthalmoplegia.