母血 羊水中sHLA-G1 PGE2的变化与分娩发动的关系

Changes of sHLA-G1 and PGE2 in Blood and Amniotic Fluid During Onset of Normal Labor

目的研究足月妊娠分娩发动前后母血、羊水中sHLA-G1和PGE2的变化及相关性并探讨其在分娩发动中的作用。方法应用ELLISA法检测孕晚期未临产组(剖宫产组)和临产组母血和羊水中sHLA-G1水平和PGE2浓度的变化水平。结果①与未临产组相比临产组羊水中HLA-G1表达下降,差异有显著性(P<0.001)。②与未临产组相比临产组羊水中PGE2水平升高,差异有显著性(P<0.001)。结论分娩发动时母血和羊水中HLA-G1下降从而激活各种免疫细胞,引起细胞分泌PGE2显著增加,与分娩的发动有一定的关系。

Objective To investigate the changes of sHLA- G1 and PGE2 in blood and amniotic fluid during the onset of normal labor. And discuss the role they take part in the onset of normal labor. Methods ELLISA was used to detect the sHLA - G1 in human blood and amniotic fluid of late pregnancy and measure the level of PGE2 in blood and amniotic fluid. Results （1）Compared with the late pregnancy group, sHLA - G1 decreased in the onset of labor group （ P 〈 0. 001 ）. （2）the PGE2 signifcantly increased in the onset of labor group （ P 〈 0. 001 ） . Conclusion The declining sHLA - G1 may activate all kinds immunity cell and regulate PGE2 secretion which take part in the labor onset.