盐酸戊乙奎醚用于小儿气管异物取出术的药效和安全性观察

Effect and safety of penehyclidine hydrochloride in treatment of removal of foreign bodies in the trachea of children

目的比较盐酸戊乙奎醚(长托宁)、阿托品在小儿气管异物取出术中的应用效果。方法l选择60例ASAⅠ级,需气管异物取出的患儿,随机分成A组(长托宁组)和B组(阿托品组),施行静脉复合麻醉。所有病例均采用DASH 4000多功能监测仪连续无创监测MAP、HR、SPO2变化,并在给药前及给药后3、6、10、15、30、60min记录以上各项参数,同时记录呼吸道分泌物量。结果B组HR和呼吸道分泌物的量较A组增高,差异有统计学意义(P<0.05),而MAP和SPO2在两组差异无统计学意义(P>0.05)。结论在小儿气管异物取出术,术前应用新型抗胆碱药盐酸戊乙奎醚比传统药物阿托品更为安全。

Objective To compare the effects of penehyclidine hydrochloride （PHC） and atropine in the treatment of removal of foreign bodies in the trachea of children. Methods There were 60 children with foreign bodies in the trachea divided into two groups randomly. Venous complicated anesthesia was used in all children with ASA T. One group was treated with PHC while the other group was treated with atropine. MAP, HR,SPO2 was checked by multi-function monitor at 0,3,6 ,10 ,15 ,30 ,60 min after using PHC or atropine. The amount of secretion in respiratory tract was also recorded at the same time. Results In the group treated with atropine the HR and the amount of secretion in respiratory tract significantly increased than that in the group treated with PHC. There were no significant differences in MAP and SPO2 between these two groups. Conclusion Pretreated with PHC could be better than atropine in the treatment of removal of foreign bodies in the trachea of children.