摘要
1例29岁女性患者因慢性肾功能不全、甲状腺功能亢进住院。为治疗窦性心动过速,给予普萘洛尔10mg,3次/d口服。患者用药前血钾水平为4.64mmol/L,治疗第9天升至6.41mmol/L,但尿量未减少,亦未发现肾功能恶化的证据。给予低钾饮食、静脉注射高渗葡萄糖、胰岛素、呋塞米,治疗后血钾仍高于正常;普萘洛尔减量后,血钾恢复正常;再次加量,血钾再次升高;停用普萘洛尔,改用美托洛尔治疗,血钾恢复正常。
A 29-year-old woman was hospitalized with chronic renal insufficiency and hyperthyroidism. She was given propranolol 10mg thrice daily for treating sinus tachycardia. Her blood potassium level was 4.64 mmol/L before propranolol therapy, and increased to 6.41mmol/L on day 9 of treatment, but his urinary volume did not decrease and no evidence showed that his renal function deteriorated. Her blood potassium level still remained elevated after treatment with low potassium diet, intravenous injection of hypertonic glucose, insulin, and furosemide. The blood potassium level returned to normal range after reducing dosage of propranolol, and elevated once more after increasing dosage again. Propranolol was discontinued and changed to metoprolol. His blood potassium level normalized.
出处
《药物不良反应杂志》
2008年第5期365-366,共2页
Adverse Drug Reactions Journal
