期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

H1-抗组胺药物的临床药理学相关问题 被引量：1

原文传递
导出
摘要 第一个H1-抗组胺药是Anne—MarieStaub和DanielBovet在研究一种药物的肾上腺素能拮抗功能时，偶然发现这种药物同时对豚鼠具有较强的抑制组胺作用。H1-抗组胺药的发现是治疗组胺介导的变应性疾病的一个重大的突破。在此基础上不同学者先后合成了第一代和第二代H1-抗组胺药，按其合成的先后依次为（择其主要者）：苯海拉明和氯苯那敏（扑尔敏）几乎同时于上世纪40年代问世；
作者 顾之燕
机构地区 北京东四西大街
出处 《中华耳鼻咽喉头颈外科杂志》 CAS CSCD 北大核心 2008年第11期875-879,共5页 Chinese Journal of Otorhinolaryngology Head and Neck Surgery
关键词 抗组胺药物 临床药理学 肾上腺素能 变应性疾病 氯苯那敏 苯海拉明 第二代 第一代
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献27

  • 1Kruszewski J. Antihistamine in allergic rhinitis. Otolaryngol Pol, 2007, 61 : 522-426.
  • 2Berger WE. The safety and efficacy of desloratadine for the management of allergic disease. Drug Saf, 2005,28: 1101-1118.
  • 3Bousquet J, Bindslev-Jensen C, Canonica GW, et al. The ARIA/ EAACI criteria for antihistamines: an assessment of the efficacy, safet and pharmacology of desloratadine. Allergy, 2004:59 Suppl 77:4-16.
  • 4Leurs R, Church MK, Taglislateta M. H1-antihistamines: inverse agonism, anti-inflammatory actions and cardiac effects. Clin Exp Allergy, 2002, 32 : 489-498.
  • 5Simons FER. Comparative pharmacology of H1 antihistamine: clinical relevance. Am J Med, 2002, 113 : 38S-46S.
  • 6Gillard M, Benedetti MS, Chatelain P, et al. Histamine HI receptor occupancy and phamaeodynamies of second generation Hi-antihistamines. Inflamm Res, 2005, 54 : 367-369.
  • 7Estelle F, Simons R, Simons KJ. Clinical pharmacology of H1- antihistamine. In: Simons FER. ed. Histamine and H1- antihistamines in allergic disease, New York: Marcel Dekker, 2002 : 141-178.
  • 8Prenner BM, Schenlel E. Allergic rhinitis: treatment based on patient profiles. Am J Med, 2006, 119: 230-237.
  • 9Pinar E, Ervigit O, Oncels C, et al. Efficacy of nasal corticosteroids alone or combined with antihistamine or montelukast in trestment of allergic rhinitis. Auris Nasus Larynx, 2008, 35 : 61-66.
  • 10Fumagalli F, Baiardini L, Pasquali M, et al. Antihistamines : do they work? further well-controlled trials involving larger samples are needed. Allergy, 2004, 59 Suppl 78 : 74-77.

二级参考文献45

  • 1Mygind N. Nasal allergy. Oxford: Blackwell, 1978. 173.
  • 2Saito H, Howie K, Wattie J,et al. Allergen-induced murine upper airway inflammation: local and systemic changes in murine experimental allergic rhinitis. Immunology, 2001, 104: 226-234.
  • 3Togias AG. Systemic immunologic and inflammatory aspects of allergic rhinitis. Allergy Clin Immunol, 2000, 106( Suppl 5 ) :S247-250.
  • 4Borish L Allergic rhinitis: systemic inflammation and implicationsfor management. J Allergy Clin Immunal, 2003, 112: 1021-1031.
  • 5Milgrom H. Attainments in atop: special aspects of allergy and IgE.Adv Pediatr, 2002, 49: 273-287.
  • 6Dumitrascu D. Allergy as a systemic disease. Roum Arch Microbiol Immunol, 2001, 60:227-236.
  • 7Braunstahl GJ, Fokkens WJ, Overbeck SE, et al. Mucosal and systemic inflammatory changen in allergic rhinitis and asthma: a comparison between upper and lower airways. Clin Exp Allergy,2003. 33:579-587.
  • 8Undem B, Kajekar R, Hunter D, et al. Neural integration and allergic disease. J Allergy Clin Immunol, 2000, 161 :$213-229.
  • 9Myers A, Kajeka R, Undem B. AHergic imqammation-induced neuropeptide production in rapidly adapting afferent nerves in guinea pig airways. Am J Physiol Lung Cell Mol Physiol,2001, 282:775-781.
  • 10Braunstahl GJ, Hellinga PW. Allergic rhinitis and asthma: the link further unraveled. Curt Opin Pulm Med, 2003, 9: 46-51.

共引文献42

同被引文献6

引证文献1

二级引证文献4

中华耳鼻咽喉头颈外科杂志
2008年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部