期刊文献+

nm23-H1蛋白表达在非小细胞肺癌淋巴结转移的意义 被引量:2

Expression of nm23-H1 in the Lymph Node Metastasis of Non-small Cell Lung Cancer
下载PDF
导出
摘要 目的:探讨nm23-H1蛋白在非小细胞肺癌(NSCLC)中的表达及与淋巴结转移的关系。方法:应用免疫组织化学法检测60例非小细胞肺癌组织中nm23-H1基因蛋白的表达。结果:NSCLC无淋巴结转移组nm23-H1蛋白阳性表达率为82.76%(24/29),高于NSCLC伴有淋巴结转移组45.16%(14/31),两者差异有统计学意义(P<0.01)。结论:NSCLC中nm23-H1蛋白低表达易发生淋巴结转移,检测nm23-H1蛋白可在一定程度上评估NSCLC的预后。 Objective: To explore the relationship between the expression of nm23-H1 and the lymph node metastasis of nonsmall cell lung cancer. Methods: The expressions of nm23-H1 in 60 cases with non-small cell lung cancer were detected by immunohistochemieal staining. Results: In the groups with and without lymph node metastasis, the positive rates of nm23-H1 were 45. 16%(14/31) and82.76%(24/29) respectivelywithsignifieantdifferenee(P〈0.01). Condusion: The low expression of nm23- H1 is related to the lymph node metastasis of NSCLC.
出处 《肿瘤预防与治疗》 2008年第4期381-382,372,494,共4页 Journal of Cancer Control And Treatment
关键词 非小细胞肺癌 NM23-H1 淋巴结转移 免疫组化 NSCLC nm23-H1 Lymph Node Metastasis Immunohistochemistry
  • 相关文献

参考文献12

  • 1[1]Toloza EM,Roth JA,Swisher SG.Molecular events in bronchogenic carcinoma and their implications for therapy[J].Semin Surg Oncol,2000,18:91-99.
  • 2[2]Steeg PS,Bevilacqua G,Kopper L,et al.Evidence for a novel gene associated with row tumor metastatic potential[J].J Natl Cancer Inst,1988,80(3):200-204.
  • 3[3]Suzuki E,Ota T,Tsukuda K,et al.Nm23-H1 reduces in vitro cell migration and the liver metastatic potential of colon cancer cells by regulating myosin light chain phosphorylation[J].Int J Cancer,2004,108(2):207-211.
  • 4[4]Qian M,Feng Y,Xu L,et al.Expression of antimetastatic gane nm23-H1 in epithelial ovarian cancer[J].J Chin Med(Engl),1997,110(2):142-144.
  • 5[5]Gunduz M,Ayhan A,Gullu I,et al.Nm23 Protein expression in larynx cancer and the relationship withmetastasis[J].Eur J Cancer,1997,33(14):2338-2341.
  • 6[6]Guo X,Min H Q,Zeng MS,et al.Nm23-H1 expression in nasopharyngeal carcinoma:correlation with clinical outcome[J].Int J Cancer,1998,79(6):596-600.
  • 7[7]Iizuka N,Hirose K,Noma T,et al.The nm23-H1 gene as a predictor of sensitivity to chemotherapeutic agents in esophageal squamous cell carcinoma[J].Br J Cancer,1999,81 (3):469-475.
  • 8[8]Higashiyama M,Doi O,Yokouchi H,et al.Immunohistechemical analysis of nm23 gene product/NDP kinase expression in pulmonary adenocareinoma:lack of prognostic value[J].Br J Cancer,1992,66(3):533-536.
  • 9[9]Ohta Y,Nozaki Z,Nozawa H,et al.The predictive value of vascular endothelial growth factor and nm23 for the diagnosis of occult metastasis in non -small cell lung cancer[J].Jpn J Cancer Res,2001,92(3):361-366.
  • 10陈晓峰,周清华,石应康,张尚福,张声,成娘,杨俊杰,赵雍凡,蒋光亮,伍伫,杨振华.转移抑制基因nm23-H_1在人非小细胞肺癌中的表达研究[J].中国胸心血管外科临床杂志,1997,4(2):80-82. 被引量:18

共引文献55

同被引文献15

引证文献2

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部