摘要
目的:探讨nm23-H1蛋白在非小细胞肺癌(NSCLC)中的表达及与淋巴结转移的关系。方法:应用免疫组织化学法检测60例非小细胞肺癌组织中nm23-H1基因蛋白的表达。结果:NSCLC无淋巴结转移组nm23-H1蛋白阳性表达率为82.76%(24/29),高于NSCLC伴有淋巴结转移组45.16%(14/31),两者差异有统计学意义(P<0.01)。结论:NSCLC中nm23-H1蛋白低表达易发生淋巴结转移,检测nm23-H1蛋白可在一定程度上评估NSCLC的预后。
Objective: To explore the relationship between the expression of nm23-H1 and the lymph node metastasis of nonsmall cell lung cancer. Methods: The expressions of nm23-H1 in 60 cases with non-small cell lung cancer were detected by immunohistochemieal staining. Results: In the groups with and without lymph node metastasis, the positive rates of nm23-H1 were 45. 16%(14/31) and82.76%(24/29) respectivelywithsignifieantdifferenee(P〈0.01). Condusion: The low expression of nm23- H1 is related to the lymph node metastasis of NSCLC.
出处
《肿瘤预防与治疗》
2008年第4期381-382,372,494,共4页
Journal of Cancer Control And Treatment