药代动力学-药效动力学结合模型在中药研究中的应用

Appliance of PK/PD modeling in traditional chinese medicine research

药代动力学-药效动力学(Pharmacokinetic-pharmacodynamic,PK/PD)结合模型是研究中药体内代谢过程、药物效应及二者联系的有效工具,对于中药作用机制研究、临床用药优化有重要的参考价值。建立能体现中医药特色的PK/PD结合模型十分必要。该文针对目前PK/PD结合模型在中药研究领域的应用现状作了系统的阐述,并就中药效应物质基础的确定、效应指标的选择等关键问题进行探讨并提出建议,以期为今后的相关研究提供参考。

Pharmacokinetic-pharmacodynamic （PK/PD） modeling,as an available tool accounting for the interrelated dynamic connection between the dosage and efficiency of drugs, plays an important role in the field of studying the mechanism and optimizing the clinical administration of traditional Chinese medicine （TCM）. Based on the general illustration on the foregoing application of PK/PD modeling, the present work investigates the involving challenges in the field, such as the selection of the targetchemical composition and effect mark. In accordance with the unique properties of TCM, further, the related suggestions, mainly focusing on determining the substances based on the effect and establishing the multi-index appraise system, are put forward as reference for the following research work.