1—(4′—哌啶苯基)—3—酰氨基—4—取代苯基2—氧吖丁啶甲碘化物的合成

Synthesis of 1-(4-Piperidino-phenyl)-3-Amido-4-Substituted Phenyl-2-Oxo-Azetidine Metho-iodides

用对硝基氯苯为原料,经七步反应合成具有季铵盐类结构的8种新标题化合物。经元素分析、核磁共振氢谱、红外吸收光谱和质谱证实。这种类型的2-氧吖丁啶化合物尚未见诸文献。对腊样芽胞杆菌产生的β-内酰胺酶均有不同程度的抑制作用。

A convenient method, starting from 4-nitrochlorobenzene by 7 steps, is reptorted for the synthesis of the 8 novel title compounds. This is the first time to design the oxoazetidinones which consist of the quarternary ammonium salt structure. All the title compounds have been identified via elemental analysis, IR, ~1H NMR and MS. And all of them show inhibitory activity against β-lactamase.