参松养心胶囊对兔实验性室性心律失常的预防作用

The prevention effect of Shensong Yangxin Capsule on ventricular arrhythmia:Experimental study

目的观察并比较参松养心胶囊、美西律对兔实验性室性心律失常的预防作用。方法用氯化钡(4 mg/kg)耳缘静脉推注制作兔室性心律失常模型,观察参松养心胶囊、美西律对心律失常的预防效果。结果(1)参松养心胶囊在推迟室性心律失常出现时间、缩短室性心律失常持续时间和心律失常恢复时间优于美西律(P<0.05)。(2)参松养心胶囊在减少室早、室速的发生率略差于美西律(P<0.05)。结论参松养心胶囊对氯化钡所致心律室性心律失常的预防作用略优于美西律。

Objective To explore the preventive function of Shensong Yangxin Capsule and Mexiletine on the ventricular arrhythmia for the experimental rabbits. Methods Observe the preventive function of Shensong Yangxin Capsule and mexiletine for ventricular arrhythmia by the model of experimental rabbit ventricular arrhythmia produced by barium chloride （4mg/kg） ear - intravenous injection. Results 1. It demonstrated that Shensoug Yangxin Capsule was better than Mexiletine in postponing or shorten ventricular arrhythmias, and promoting the recovery time （ P 〈 0.05 ） of ventricular arrhythmias. 2. It showed that Shensong Yangxin Capsule was no better than Mexiletine in reducing the incidence of ventricular tachycardia （ P 〈 0.05 ）. Conclusion The preventive function of Shensong Yangxin Capsule was preferable than Mexiletine in treating barium chloride - induced ventricular arrhythmia.