桂枝附子汤治疗佐剂性关节炎大鼠IL-1β、PGE_2水平影响的实验研究

Experimengtal effect of Guizhi Fuzi Decoction on the levels of interleukin 1β,prostaglandin E_2 in adjuvant-induced arthritis rats

[目的]探讨桂枝附子汤治疗佐剂性关节炎大鼠血清白介素-1β(IL-1β)及前列腺素E2(PGE2)水平的影响。[方法]通过比较各组大鼠血清中IL-1β、PGE2的变化来判定桂枝附子汤的疗效。[结果]血清中IL-1β、PGE2含量,空白组和雷公藤组、桂附组及雷公藤组和桂附组比较没有显著差异;而模型组和空白组、雷公藤组、桂附组比较差异显著。[结论]桂枝附子汤能控制佐剂性关节炎大鼠血清中IL-1β、PGE2等炎症介质的活性,对类风湿关节炎有治疗作用。

[ Objective] To explore the changes of interleukin 1 β （ IL - 1β） , prostaglandin E2 （ PGE2 ） in rats with adjuvant - induced arthritis after administration of Guizhi Fuzi Decoction. [ Methods ] By comparing each group the Levels of IL - 1β, PGE2 in AA to determine the effect of Guizhi Fuzi Decoction. [ Results ] For the content of IL - 1β, PGE2 in the serum of rats, between normal control group and Leigongteng group, Guizhi Fuzi Decoction group including Leigongteng group and Guizhi Fuzi Decoction group there was no significant difference, but between model group and normal control group, Leigongteng group, Guizhi Fuzi Decoetion group there were significant differenees.[ Conclusion ] Guizhi Fuzi Decoction can control the activities of Inflammatory mediators like the IL- 1βand PGE2 in the serum of adjuvantinduced arthritis rats, it is effective to rheumatoid arthritis.