血管复生素治疗血栓闭塞性脉管炎的基础和临床研究

Fundamental and clinical Studies on Treatment of Thromboangitis Obliterans by A New Drug TAOC

将中药白果、人参、葱根等发酵制成治疗血栓闭塞性脉管炎的新药血管复生素。基础研究和临床应用证明血管复生素：①具有类似吗啡的镇痛作用，其镇痛率与对照组相比，有非常显著差异性（Ｐ＜０．００１）；②具有很强的抗炎作用，抗炎抑制率达７５．３３％，和对照组相比，具有非常显著差异性（Ｐ＜０．００１）；③具有显著扩张病变血管的功能，扩张强度与对照组相比，有明显差异性（Ｐ＜０．０１）；④可选择性地抑制血管内皮细胞和成纤维细胞的增生。观察６８例，６６例获近期痊愈，治愈率为９７．０２％，仪器检查闭塞的血管恢复血流；免疫学检测，血清中抗血管抗体消失。证明该药具有抗栓溶栓。

A new drug Xueguan Fushengsu(TAOC)was prepered by fermentation of medicinal herbs of gingo,ginseng,green onion roots,etc,by biological techniques and immunologic methods to treat patients with thromboangitis obliterans.Fundamental and clinical studies revealed TAOC was effective (1)in morphine-like analgesic action,the pain relieving rate was very significantly different from that in the control group (P<0.001);(2)with very strong anti inflammatory effect,the inflammation-inhibition rate being 75.33%,very significantly different from control(P<0.001);(3)with merked function of vasodilation(P<0.01);(4)in selectively inhibition of proliferation of vascular endothelial cells and fibroblasts.A series of 68 cases were observed,of them 66 were cured after 3 months of treatment,the short term cure rate was 97.02%.Examination of the formerly obliterated vessels by instruments showed resumption of blood flow.Immunologic determinations showed disappearance of serum anti vessel antibodies.It was suggested that the drug TAOC was of the effects of antithrombus,thrombolysis,and of inhibiting the growth of anti vessel antibodies.