抗焦虑抑郁治疗对冠心病患者生活质量的影响

The effects of anti-anxiety and depression therapy on life quality of patient with coronary heart diseases

目的观察抗焦虑抑郁治疗对冠心病患者生活质量的影响。方法对冠心病患者进行症状自评量表(SCL-90)测评阳性患者50名,随机分成两组,第1组26人,第2组24人;量表测评阴性的患者14人为第3组。三组患者均用左旋肉碱治疗6个月,第1组同时加用氢溴酸西酞普兰。治疗前后进行生活质量的评定包括SCL-90、心血管患者生活质量量表(QOL)及心功能指标(FS、SV、CO、EF、E/A)。结果(1)治疗后各组患者的生活质量(QOL)均有显著好转,第1组治疗前(35.4±6.61)vs治疗后(19.93±2.64),P<0.01;第二组治疗前(37.20±6.83)vs治疗后(25.68±6.49),P<0.01;第三组治疗前(32.31±5.23)vs治疗后(21.38±4.43),P<0.01。第1组QOL(P<0.05)的好转更明显。(2)三组之间的SCL-90比较示抑郁、焦虑、敌对评分和总均分以第1组中下降最显著。(3)第1组的心脏收缩和舒张功能都显著提高,第3组仅收缩功能显著提高,第2组无改变。结论抗焦虑抑郁治疗增加常规药物疗效,提高冠心病患者的生活质量。

Objective To evaluate the effects of anti-anxiety and depression therapy on life quality of patients with coronary heart disease. Methods Coronary heart disease patients were investigated with the Self-report Inventory Symptom Check-list 90 （SCL-90）. 50 patients with positive results in scale were divided into two groups randomly, groupl （ n = 26） and group 2 （ n = 24）, and those with normal scores （ n = 14） belonged to group 3. All patients were treated with L-carnionc for six months, while the group 1 had anti-anxiety and depression therapy at same time. Before and after therapy, quality of life was assessed with SCL-90 and Quality of Life for Cardiovascular Disease （QOL） Scales. Moreover some clinical tests were made such as cardiac function. Result （ 1 ） After therapy, the QOL score had significant improved in all three groups with the greatest improvements in the group 1. （2） The decrease of depression, anxiety, hostility factor scores and total average score decreased mostly in group 1. （ 3 ） The group 1 had significant improvements in systolic and diastolic heart function after therapy, but not in group2. The group 3 only had significant improvements in systolic heart function.. Conclusion Anti-anxiety and depression therapy can enhance the effects of common drugs and improve the quality of life in patients with coronary heart disease.