不同剂量人血丙种球蛋白治疗小儿特发性血小板减少性紫癜疗效观察

Clinical efficacy of different dosages of immunoglobulin in children with idiopathic thrombocytopenic purpura

本组应用不同剂量人血雨种球蛋白治疗小儿特发性血小板减少性紫癜22例，其中肌注丙球每日320mg，连用5日10例，静脉输注低pH静脉注射人血丙球每日400mg／kg，连用5日8例；每日输注1g／kg1次4例。以T检验方法计算观察。3组治疗后血小板计数分别为127.5±53．71×109／L,206．5±144．84×109／L，238．25±110．27±109／L，3组治疗后血小板数比较无统计学差异，即3组治疗特发性血小板减少性紫癜都有效。

Clinical efficacy of different dosages of immunoglobulin was studied in children with idiopathic thrombocytopenic purpura. Three groups of 22 cases of ITP were studied:a dosage of 320 mg/day for five days intramuscularly in 10 patients (group Ⅰ); intravenous immunoglobulin in a dosage of 400mg/kg/day for five days in 8 patients (group Ⅱ );Intravenous immunoglobulin in a does of 1g/kg/day in 4 patients (group Ⅲ). The platelet count were done before and after treatment. Results showed after treatment in three groups: the group Ⅰ,Ⅱ,Ⅲ were P<0. 001, P<O. 05 P<O. 05,respectively. After treatment, an average platelet counts were 127. 5±53. 71×109/L, 206. 5±144. 84×109/L, 238. 25±110.27×109/L,respectively. There was no statistically significant difference among different dosages of immunoglobulin used in children.