川崎病患儿外周血中红细胞和血小板参数的变化

THE CHANGES OF PARAMETERS OF RED BLOOD CELL AND PLATELET IN PERIPHERAL BLOOD IN KAWASAKI DISEASE

川崎病（KD）是一种以全身血管炎为主要病理改变的急性发热、出诊性疾病：多数患儿还可以出现贫血、血小板数升高等改变。本文通过全自动血细胞计数仪对KD患儿的外周血红细胞和血小板参数的观察，发现其贫血患儿的平均红细胞体积（MCV）降低、红细胞分布宽度（RDW）增高，为小细胞不均一性贫血，符合缺铁性贫血的表现。KD患儿血小板数普遍较高，尤其病程早期的平均血小板体积（MPV）增高，提示有血小板增多的趋势和在血管炎性反应中的重要作用。因此，对KD患儿应尽早使用抗血小板药物，在治疗过程中注意对缺铁性贫血的纠正。

Kawasaki desease (KD) is an acute feverish illness with prominent mucocutaneous and cardiovascular manifestations. Most of the patients may have anemia and thrombocytosis. In order to determine the characteristics of anemia and the platelet count, we observed the parameters of red blood cell and blatelet in peripheral blood of 21 cases of KD patients by the automneic complete blood cell counter. It was found that the anemia children with KD had low mean corpuscular volume (MCV) and high red blood cell distribution width (EDW),suggesting microcytic heterogeneous anemia and according with iron deficiency anemia. The platelet count was high respecially in the early stage, the mean platelet volume(MPV) rose suggesting the tendency of thrombocytosis and the important effect of the platelet on the vasculitic reaction. Therefore, anti-platelet agents should be used early, and in the treatment of KD, it is important to pay attention to correct iron deficiency anemia.