小儿恶性淋巴瘤病理学、免疫学、细胞遗传学、超微病理学的临床研究

STUDY OF PATHOLOGY, IMMUNOLOGY, CYTOGENETICS, ULTRASTRUCTURE AND CLINICS IN CHILDREN WITH MALIGNANT LYMPHOMA

对35例小儿恶性淋巴瘤（ML）经病理学、免疫学、细胞遗传学及超微病理学四个方面进行研究，旨在了解其间的相互联系及其临床意义。结果表明ML免疫分型呈多样化改变，免疫分型与病理类型的恶性程度呈正相关。淋巴结染色体核型异常率高达100％，霍奇金瘤的染色体核型变化较非霍奇金淋巴瘤复杂，并与病理类型有一定相关性。15例ML同时进行了病理及电镜分型诊断，病理亚型诊断答合率80％，电镜亚型诊断符合率93．3％。提示ML是一组高度异质性恶性肿瘤，上述四方面的改变与肿瘤细胞分化密切相关，在病理分型的基础上结合电镜检查，可提高ML各亚型分类的准确性。

Thirty-five children with the malignant lymphoma (ML) had been studed by the methods of pathology, immunology, cytogentics, ultrastructure, for searching the relationship and clinical significance of them. The results showed that the ML were the malignant tumours with the high heterogeneity which had high varieties in pathology, immunology, cytogenetics, ultrastructure and were closely associated with defferentiation of tumour cell. The chromosomc abnormol rated of lymphocyte in lympho-node was 100%, the chroosome karyotypes in Hodgkin's disease (HD) were more complex than the Non-hodgkin's lymphoma (NHL) and they were alkl associated with pathology classification. Fifteen cases of ML had been classified by light microscope and electron microscope. The accurated rates of diagnosis were 80. 0% by first method and 93. 3% by ultrastructure. The combination of these two methods will increase benefit for the treatment and prognosis of ML.