温胆汤对MK801诱发精神分裂症模型鼠突触传递效能的影响

Effect of synaptic transmission activity of Wendan Decoction on Rats with Schizophrenia

目的:研究温胆汤对精神分裂症模型鼠突触传递效能的影响。方法:将30只SD大鼠,随机分三组,分别为正常组(A)、模型组(B)及温胆汤组(C),A、B组灌胃生理盐水,C组灌胃温胆汤,每天一次,21天后地卓西平马来酸盐(MK801)造模诱发精神分裂症,3天后采用ASB240U生物信号采集处理分析系统,进行LTP诱发实验并观测和记录诱发电位。结果:B组大鼠LTP诱发成功率较A组和C组明显减少(P<0.05);C组大鼠有PS峰潜伏期的缩短,而B组大鼠无明显PS峰潜伏期缩短现象。结论:温胆汤能改善精神分裂症模型大鼠突触传递的效能。

Objective ：To study the effect of synaptic transmission activity of Wendan Decoction on Rats with Schizophrenia. Methods：30 SD rats were divided three groups by random. They were nomal group（ A）, model group （13） and Wendan Decoction group（C） respectively. The A, B groups were lavaged Sodium Chloride and the C group was lavaged Wendan Decoction every day. It was lasting 21 days. Then the model of schizophrenic rats were created by MK801. After three days deploying ASB240U biont singal collection management analytical system,Long-term potentiation（LTP） was induced. Evoked potentia was surveying and recording. Results：Inducion achievement ratio of Group B was lower than that of Group A and Group C （P 〈 0.05 ）. Incubation period of Group C declined but that of Group B. Conclusions：Wendan Decoction can reninforce the activity of synaptic transmission of schizophrenic rats.