玉屏风水提液对环磷酰胺致骨质疏松模型大鼠骨代谢的影响

Effect of Yupingfeng Extract on Bone Metabolism in Model Rats with Osteoporosis Induced by Cyclophosphamide

目的:研究玉屏风水提液(YPF)对环磷酰胺(CP)导致的骨质疏松的防治作用,并探讨CP对大鼠骨钙、骨磷、骨镁及骨羟脯氨酸含量的影响。方法:40只大鼠随机分为4组,即正常对照、CP、YPF、碳酸钙维生素D组。于实验第15天处死大鼠,取左侧股骨进行骨钙、骨磷、骨镁及骨羟脯氨酸含量测定。结果:与正常对照组比较,CP组各项指标含量均显著减少;与CP组比较,YPF、碳酸钙维生素D组均可提高大鼠骨钙、骨磷、骨镁及骨羟脯氨酸含量。结论:CP可引起大鼠骨钙、骨磷、骨镁及骨羟脯氨酸含量下降,YPF对此有防治作用。

OBJECTIVE： To study the effect of Yupingfeng（YPF） extract on Ca, P, Mg and hydroxyproline of bone in model rats with osteoporosis induced by cyclophosphamide（CP） and to discuss the preventive and therapeutic effect of YPF extract on CP-induced osteoporosis.METHODS： A total of 40 rats were randomly divided into four groups： control group, CP group, YPF extract group, and calciμm carbonate ＋ Vit D group. The rats were sacrificed at 15 days of experiment, and the levels of Mg,Ca,P and hydroxyproline of left femoral bone were determined. RESULTS： Compared with control group,levels of different index with CP group was significantly decreased;compared with CP group,levels of Ca, Mg,P and hydroxyproline of bone in rats treated with YPF extract were significantly increased.CONCLUSION：CP may induce decrease of levels of Ca, Mg,P and hydroxyproline of bone, however, on which YPF extract has preventive and therapeutic effect.