急性白血病患儿血清肿瘤坏死因子a的活性变化及临床意义

ACTIVITY CHANGES AND CLINICAL SIGNIFICANCE OF SERUM TUMOR NECROSIS FACTOR-alpha IN CHILDREN WITH ACUTE LEUKEMIA

用放射免疫方法测定了2O例正常儿童及40例急性白血病（AL）患儿化疗前后血清肿瘤坏死因子（TNF－a）浓度。结果；在AL诊断时，TNF－a水平显著升高1当患儿获得部分缓解至完全缓解时，TNF－a水平呈梯形降低，其最低值仍高于健康儿童（P＜O．01～0．05）；22例急性淋巴细胞白血病（ALL）患儿TNF－a水平在任何阶段都比18例急性非淋巴细胞白血病（ANLL）患儿低（P＜0．o1）；TNF－a水平和临床疗效之间显示负相关性。因此，作者们认为测量TNF－a水平可作为一项判断AL疗效和预后的临床指标。

20 normal children and 40 children with Acute leukemia (AL), before and after of chemotherapy, were measured Serum Tumor Necrosis Factor-alpha (TNF-a) Concentration by radioimmunoassay. The results were as follows; The TNF-a levels at the diagnosis AL,were markedly elevated; when the patients achieved from part to complete remission, The TNF-a levels showed a ladder-shaped drop, but the lowest value of TNF-a were still higher than those of healthy Subjects (p<0. 01~0. 05); At any period, the TNF-a levels in 22 children with acute lymphoblastic leukemia (ALL) were lower than those in 18 chiedren with acute nonlymphoblastic leukemia (ANLL) (P<0.0.01 ). The negative interrelation appear belfwecn the TNt-a levels and the clinical curative effect. The authors therefore, think that survey the 'rNF'-a levels may as a clinical target to judge AL curative effect and prognosis.