碳环核苷的合成研究进展

Progress in the Synthesis of Carbocyclic Nucleosides

碳环核苷是一类结构特殊且具有多种生物活性,其中特别是抗病毒活性的核苷衍生物.目前,碳环核苷的合成及生物活性筛选已成为新药研究领域的热点之一.综述了近年来各类碳环核苷的合成研究进展,并对不同合成路线作了简要分析和评论.

Carbocyclic nucleosides are nucleoside derivatives with special structures and interestmg bioactivities, especially antiviral activities. In the past decades much attention has been paid to the synthesis and bioactivity screen of carbocyclic nucleosides in searching for new antiviral drugs. In this paper, the synthesis of various carbocyclic nucleosides is reviewed and different synthetic routes are analyzed briefly.