摘要
目的研究低分子量肝素(LMWH)对进展期胃癌患者血浆组织因子(TF)、组织因子通道抑制物(TFPI)水平的影响。方法采用酶联免疫吸附法检测58例Ⅲ期或Ⅳ期胃癌患者和30名正常人血浆TF、TFPI的水平。结果进展期胃癌患者血浆TF表达水平较正常人明显升高,TFPI表达水平则明显低于正常人,差异均有统计学意义(P<0.05)。LMWH能增加进展期胃癌患者血浆TFPI表达水平,差异有统计学意义(P<0.05);而血浆TF表达水平与治疗前比较差异无统计学意义(P>0.05)。结论LMWH能促进进展期胃癌患者血浆TFPI的表达。
Objective To study the effect of Low-molecular weight heparins on the expression levels of plasma tissue faetor（TF） and tissue factor pathway inhibitor （TFPI） in patients with advanced gastric cancer. Methods The expression levels of plasma TF and TFPI were measured by ELISA technique in 58 patients with stage Ⅲ or Ⅳ stage gastric cancer and in the 30 normal controls. Results The level of plasma TF was significantly elevated and the level of plasma TFPI was markedly decreased in patients with advanced gastric cancer compared with those of the normal controls （P〈0.05）; lowmolecular weight heparins enhanced the levels of plasma TFPI in patients with advanced gastric cancer （P〈0.05）,but it did not affect the levels of plasma TF （P〉0.05）. Conclusion Low-molecular weight heparins promotes the levels of plasma TFPI in patients with advanced gastric cancer.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2008年第5期789-790,800,共3页
Suzhou University Journal of Medical Science
基金
无锡市社会发展计划资助项目(LE00615)
苏州市社会发展计划资助项目(2008-36)
关键词
低分子量肝素
恶性肿瘤
组织因子
组织因子通道抑制物
low-molecular weight heparins
malignant tumor
tissue factor
tissue factor pathway inhibitor
