脱氧胆酸手性分子钳的微波合成及其对中性分子的识别性能研究

Microwave assisted synthesis of chiral molecular tweezers based on deoxycholic acid and its recognition properties for neutral molecules

在微波辐射条件下,以脱氧胆酸甲酯为间隔基,高产率合成了5个脱氧胆酸手性分子钳人工受体,其结构经IR,1HNMR,MS及元素分析确证。用差紫外光谱法测定了其对中性分子的识别性能。实验结果表明,这类分子钳人工受体对所考察的客体分子有良好的识别作用,主客体间形成1∶1型主客体配合物,受体5d对苯胺的结合常数高达14171.39 M-1。

Five chiral molecular tweezer receptors are synthesized in good yields by using deoxycholic acid as spacer under microwave irradiation. Their structures are characterized by IR, ^1H NMR, MS spectra and elemental analysis. The binding properties for neutral molecular are examined by UV-visible spectra titration. The restdts show that the molecular tweezers 5a ～ 5e have good recognition properties for the neutral molecular examined and the supramolecular complexes formed between the hosts and guests consist of 1：1 host and guest molecules. The association constant of receptor 5d with aniline reachs 14171.39 M^-1.