胰腺星形细胞活化及信号转导

Pancreatic Stellate Cell Activation and Signal Transduction

胰腺纤维化是慢性胰腺炎的主要病理学特征,而活化的胰腺星形细胞(PSC)是胰腺纤维化发生的始动细胞,也是纤维化过程中的主要效应细胞。国内外研究发现多种因素,如细胞因子(常见的有血小板衍化生长因子、转化生长因子β1、白细胞介素10)、激活蛋白、氧应激及细胞内压力等诸多因素,均可通过各自的作用来影响PSC的活性,最终通过丝裂原活化蛋白激酶途径、TGF-β/Smad信号转导蛋白、过氧化物酶体增殖物激活受体γ等细胞内信号调节PSC的活化、增殖及胰腺慢性炎症和纤维化形成过程。

Chronic pancreatitis （CP） is characterized by progressive pancreatic fibrosis, and activated pancreatic stellate ceils （PSCs） play an important role in pancreatic fibrosis and chronic inflammation. Many kinds of cytokines, such as Platelet derived growth factor, transforming growth factor betal and interleukin 10 and leukomonocyte and so on, activator proteins （AP）, oxidative stress and externally applied pressure all can affect the activity of pancreatic stellate cells by respective effects, and then through different signal transductions（ as mitogen-activated protein kinase （MAPK） ,TGF beta/Smad signal transducer and peroxisome proliferators-activated receptor gamma （PPAR-β） to regulate activation, proliferation of PSC and chronic inflammation and fibrosis formation process.